dc.contributor.author |
Kanui, Titus I. |
|
dc.contributor.author |
Karim, Farzana |
|
dc.contributor.author |
Mbugua, Susan |
|
dc.date.accessioned |
2015-01-20T06:26:30Z |
|
dc.date.available |
2015-01-20T06:26:30Z |
|
dc.date.issued |
1993 |
|
dc.identifier.citation |
Neuroreport: Volume 4 - Issue 1 |
en_US |
dc.identifier.uri |
http://journals.lww.com/neuroreport/abstract/1993/01000/effects_of_codeine,_naproxen_and_dexamethasone_on.6.aspx |
|
dc.identifier.uri |
http://hdl.handle.net/123456789/627 |
|
dc.description.abstract |
A DILUTE solution of formalin (20 [mu]1 of 10% formalin) was injected subcutaneously in the dorsal right hind paw of the naked mole-rat. The injection of the dilute formalin produced two periods of pain behaviour, the early (0-5 minutes) and the late phase (25-60 minutes). These were quantified as the total time spent licking the injected paw. Codeine phosphate (10, 25 or 50 mg kg-1) significantly reduced pain behaviour in both the early and late phase. Codeine administration also induced aggressive, hyperactive behaviour and motor impairment that was nalox-one (2 mg kg-1) reversible. Naproxen (200 mg kg-1) and dexamethasone phosphate (30 mg kg-1) significantly reduced licking activity in the late phase only. |
en_US |
dc.language.iso |
en |
en_US |
dc.title |
Effects of codeine, naproxen and dexamethasone on formalin-induced pain in the naked mole-rat |
en_US |
dc.type |
Article |
en_US |