dc.contributor.author |
Mulinge, Martin M. |
|
dc.contributor.author |
Coddens, Annelies |
|
dc.contributor.author |
Verdonck, Frank |
|
dc.contributor.author |
Goyvaerts, Els |
|
dc.contributor.author |
Miry, Cora |
|
dc.contributor.author |
Goddeeris, Bruno |
|
dc.contributor.author |
Duchateau, Luc |
|
dc.contributor.author |
Cox, Eric |
|
dc.date.accessioned |
2014-12-15T07:41:53Z |
|
dc.date.available |
2014-12-15T07:41:53Z |
|
dc.date.issued |
2008-01-01 |
|
dc.identifier.citation |
Veterinary Microbiology Volume 126, Issues 1–3, 1 January 2008, Pages 210–215 |
en_US |
dc.identifier.issn |
0378-1135 |
|
dc.identifier.uri |
http://www.sciencedirect.com/science/article/pii/S0378113507003215 |
|
dc.identifier.uri |
http://hdl.handle.net/123456789/435 |
|
dc.description |
doi:10.1016/j.vetmic.2007.06.021 |
en_US |
dc.description.abstract |
F18+Escherichia coli infections causing post-weaning diarrhoea and/or oedema disease are a major cause of economic losses in pig industry. To date, no preventive strategy can protect pigs from F18+E. coli infections. One of the most attractive approaches to eliminate F18+E. coli infections is the selection for pigs that are resistant to F18+E. coli infections. However, this strategy was not believed to be favourable because of reports of genetic association with the stress-susceptibility gene in the Swiss Landrace. To investigate this potential association more thoroughly, 131 randomly selected Belgian hybrid pigs were genotyped for both the F18+E. coli resistance alleles (FUT1 A) and the stress-susceptibility alleles (RYR1 T) and their association was investigated by determining the linkage disequilibrium. This linkage disequilibrium (LD = − 0.0149) is close to zero and does not differ significantly from 0 (likelihood ratio test χ12=1.123, P = 0.29), demonstrating no association between the FUT1A and RYR1T alleles. Furthermore, only a small fraction (4.6%) of the Belgian pigs was found to be resistant to F18+E. coli infections. Our results suggest that selection for F18+E. coli resistant pigs might be an attractive approach to prevent pigs from F18+E. coli infections, unlike to what has previously been postulated. |
en_US |
dc.language.iso |
en |
en_US |
dc.publisher |
Elsevier |
en_US |
dc.subject |
F18+Escherichia coli (F107/86) |
en_US |
dc.subject |
Pig |
en_US |
dc.subject |
RYR1 |
en_US |
dc.subject |
FUT1 |
en_US |
dc.subject |
Porcine stress syndrome |
en_US |
dc.title |
The possibility of positive selection for both F18+Escherichia coli and stress resistant pigs opens new perspectives for pig breeding |
en_US |
dc.type |
Article |
en_US |