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Please use this identifier to cite or link to this item: https://repository.seku.ac.ke/handle/123456789/309
Title: Molecular genetic diversity of hepatitis B virus in Kenya
Authors: Ng'ang'a, Zipporah W.
Mwangi, Joseph
Songok, Elijah
Kinyua, Joyceline
Lagat, Nancy
Muriuki, Joseph
Lihana, Raphael
Khamadi, Samoel
Osman, Saida
Lwembe, Raphael
Kiptoo, Michael K.
Mwau, Matilu
Chirchir, Ruth
Mpoke, Solomon
Nyamongo, Jack
Okoth, Fred
Yamada, Rika
Kageyama, Seiji
Ichimura, Hiroshi
Keywords: Genotypes
Hepatitis B virus
Kenya
Nuclear acid testing
Issue Date: 2008
Publisher: S. Karger AG, Basel
Citation: Intervirology. 2008;51(6):417-21.
Abstract: Eight genotypes of hepatitis B virus (A-H) and subgenotypes have been recognized worldwide. However, there is limited information on prevalent genotypes in many countries in Africa. This study was undertaken to determine the hepatitis B virus (HBV) genotypes in Kenya. Seropositive HBV blood samples from a blood donor setting were used in the study. HBV genotypes were determined in 52 nucleic acid-positive samples using specific primer in a nested PCR and sequencing employed in the HBV genotyping. This study shows presence of HBV variants with genotypes A (88%), E (8%) and D (4%). In conclusion, we found that HBV genotype A is the most predominant genotype in Kenya with both subgenotype A1 and A2 present. Genotype D and E are also present in our population. This demonstrates that there could be a high genetic diversity of HBV in Kenya. Copyright 2009 S. Karger AG, Basel.
Description: doi: 10.1159/000205526.
URI: http://www.researchgate.net/publication/24174998_Molecular_genetic_diversity_of_hepatitis_B_virus_in_Kenya
http://hdl.handle.net/123456789/309
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