The effects of clonidine and yohimbine in the tail ick and hot plate tests in the naked mole rat (Heterocephalus glaber)

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dc.contributor.author Mwobobia, Royford
dc.contributor.author Klas, Abelson
dc.contributor.author Kanui, Titus I.
dc.date.accessioned 2021-04-06T11:16:22Z
dc.date.available 2021-04-06T11:16:22Z
dc.date.issued 2021
dc.identifier.citation Research square en_US
dc.identifier.uri https://assets.researchsquare.com/files/rs-362862/v1/baa47875-3967-4ce6-95c7-7569601fff8e.pdf
dc.identifier.uri http://repository.seku.ac.ke/handle/123456789/6254
dc.description DOI: 10.21203/rs.3.rs-362862/v1 en_US
dc.description.abstract Objective: The naked mole rat (NMR) (Heterocephalus glaber) is increasingly considered an important biomedical research model for various conditions like hypoxic brain injury, cancer and nociception. This study was designed to investigate the effects of clonidine and yohimbine, an alpha-2 (α2 ) adrenoceptor agonist and antagonist respectively in the tail ick and hot plate tests. Results: A signicant difference in tail ick latency was noted between saline control and 30µg/kg clonidine, which was reduced after administration of 30µg/kg yohimbine. A signicant difference in hot plate latency was also noted between saline control and 30µg/kg clodinine during the periods 30, 45, 60, 75 and 90 minutes after administration, and between saline control and 10µg/kg clonidine during 30 minutes after administration. The hot plate latency by 30µg/kg clonidine was also reduced by 30µg/kg yohimbine during 30 minutes after administration. Since the tail-ick and hot plate tests mediate the effects at spinal and supraspinal levels respectively, the present study indicates the presence and involvement of noradrenergic receptors in thermal antinociception at spinal and supraspinal levels of the NMR, similar to what has been found in other mammals en_US
dc.language.iso en en_US
dc.publisher biomed central en_US
dc.subject hot plate en_US
dc.subject clonidine en_US
dc.subject naked mole rats en_US
dc.subject noradrenergic en_US
dc.subject nociception en_US
dc.subject tail ick en_US
dc.subject yohimbine en_US
dc.title The effects of clonidine and yohimbine in the tail ick and hot plate tests in the naked mole rat (Heterocephalus glaber) en_US
dc.type Article en_US


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