Effects of tea on survival rates and liver pathology of Trypanosoma brucei brucei infected mice

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dc.contributor.author Mbuthia, S. K.
dc.contributor.author Wachira, Francis N.
dc.contributor.author Ngure, R. M.
dc.contributor.author Ouma, J.
dc.contributor.author Kagira, J. M.
dc.date.accessioned 2017-08-23T13:08:58Z
dc.date.available 2017-08-23T13:08:58Z
dc.date.issued 2011
dc.identifier.citation Journal of Protozoology Research, 21, 1-7 (2011) en_US
dc.identifier.issn 0917-4427
dc.identifier.uri https://www.researchgate.net/publication/272174498_Effects_of_tea_on_survival_rates_and_liver_pathology_of_Trypanosoma_brucei_brucei_infected_mice
dc.identifier.uri http://repository.seku.ac.ke/handle/123456789/3525
dc.description.abstract The current study investigated the effects of different types of Kenyan tea extracts on the pathogenesis ofTrypanosoma brucei brucei in a Swiss White mice model. Following infection with trypanosomes, the micewere monitored for survival and liver pathology. Tea significantly (P<0.05) enhanced the survival rate of teatreated mice. Additionally, in tea treated but infected mice, there was reduction in infiltration of inflammatorycells into the periportal and parenchymal regions as well as hepatocyte cell damage compared to the infecteduntreated animals. Green and white teas were superior in most of the above effects while black tea and oolongteas had the least effects. The tea extracts were more efficacious than dexamethasone in prolonging the life ofinfected animals. It is concluded tea can act as adjunct therapeutic agent in treatment of diseases having hepaticinflammation, including trypanosomiasis. en_US
dc.language.iso en en_US
dc.publisher National Research Center for Protozoan Diseases en_US
dc.subject Inflammation en_US
dc.subject liver pathology en_US
dc.subject survival rate en_US
dc.subject tea en_US
dc.subject trypanosomiasis en_US
dc.title Effects of tea on survival rates and liver pathology of Trypanosoma brucei brucei infected mice en_US
dc.type Article en_US

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