Strong Association Between Human and Animal Brucella Seropositivity in a Linked Study in Kenya, 2012-2013.

Show simple item record Osoro, Eric M. Munyua, Peninah Omulo, Sylvia Ogola, Eric Ade, Fredrick Mbatha, Peter Mbabu, Murithi Ng'ang'a, Zipporah W. Kairu, Salome Maritim, Marybeth Thumbi, Samuel M. Bitek, Austine Gaichugi, Stella Rubin, Carol Njenga, Kariuki Guerra, Marta 2017-07-17T09:30:11Z 2017-07-17T09:30:11Z 2015-08-05
dc.identifier.citation American Journal of Tropical Medicine and Hygiene, 2015 Aug 5; 93(2): 224–231. en_US
dc.identifier.issn 0002-9637
dc.description doi: 10.4269/ajtmh.15-0113 en_US
dc.description.abstract Brucellosis is a common bacterial zoonotic infection but data on the prevalence among humans and animals is limited in Kenya. A cross-sectional survey was conducted in three counties practicing different livestock production systems to simultaneously assess the seroprevalence of, and risk factors for brucellosis among humans and their livestock (cattle, sheep, camels, and goats). A two-stage cluster sampling method with random selection of sublocations and households was conducted. Blood samples were collected from humans and animals and tested for Brucella immunoglobulin G (IgG) antibodies. Human and animal individual seroprevalence was 16% and 8%, respectively. Household and herd seroprevalence ranged from 5% to 73% and 6% to 68%, respectively. There was a 6-fold odds of human seropositivity in households with a seropositive animal compared with those without. Risk factors for human seropositivity included regular ingestion of raw milk (adjusted odds ratio [aOR] = 3.5, 95% confidence interval [CI] = 2.8–4.4), exposure to goats (herding, milking, and feeding) (aOR = 3.1, 95% CI = 2.5–3.8), and handling of animal hides (aOR = 1.8, 95% CI = 1.5–2.2). Attaining at least high school education and above was a protective factor for human seropositivity (aOR = 0.3, 95% CI = 0.3–0.4). This linked study provides evidence of a strong association between human and animal seropositivity at the household level. en_US
dc.language.iso en en_US
dc.publisher American Society of Tropical Medicine and Hygiene en_US
dc.title Strong Association Between Human and Animal Brucella Seropositivity in a Linked Study in Kenya, 2012-2013. en_US
dc.type Article en_US

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