Acute and sub-chronic oral toxicity study of methanolic extract of Caesalpinia volkensii (harms)

Show simple item record Mbiri, Jane W. Musila, Michael N. Ngai, David N. Njagi, Shardrack M. Mbinda, Wilton M. Ngugi, Mathew P. 2017-02-09T11:41:16Z 2017-02-09T11:41:16Z 2017
dc.identifier.citation Journal of Drug Metabolism and Toxicology: 8:1 en_US
dc.identifier.issn 2157-7609
dc.description DOI: 10.4172/2157-7609.1000222 en_US
dc.description.abstract Medicinal plant Caesalpinia volkensii is used to treat Malaria, conjunctivitis, retinoblastoma, and eyelid swelling as well as gonorrhoea and bilharzia. Animal toxicity information on this plant is limited. This medicinal plant was collected in Embu County in Kenya to evaluate its Acute and sub-chronic toxicity using Wistar rats. The rats were orally administered with different doses of the plants extracts. They were weighed on first day and after every 7 days during treatment with the extract. Signs of toxicity were also observed. After 28 days, the rats were sacrificed and blood samples taken for full hemogram, renal and liver function tests. Weight of internal organs was also recorded. Data was analysed using Minitab statistical software version 17. In acute toxicity studies, C. volkensii extracts did not result to death at extract dose of 2000 mg/kg body weight. In sub-chronic toxicity studies, there was no significance difference in body weight and organ weight among the groups treated with the plant extract (p>0.05). Treatment with extract dose of 1000 mg/kg body weight resulted in significant increase in total bilirubin and aspartate aminotransferase (P˂0.05). In addition, 100 mg/kg body weight resulted in significant decrease in haemoglobin and haematocrit. Qualitative phytochemical screening confirmed the presence of various phytochemicals which have the ability to protect erythrocytes from oxidative damage as well as erythropoietin stimulatory activities. It was therefore concluded that methanolic leaf extract of C. volkensii is safe for acute oral administration. However, care should be exercised in sub-chronic exposure at 1000 mg/kg body weight and above to avoid liver injury. en_US
dc.language.iso en en_US
dc.publisher OMICS International en_US
dc.subject Bioassay en_US
dc.subject Blood Clotting en_US
dc.subject Anticoagulant en_US
dc.subject Haemoglobin en_US
dc.subject Mortality en_US
dc.title Acute and sub-chronic oral toxicity study of methanolic extract of Caesalpinia volkensii (harms) en_US
dc.type Article en_US

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