dc.contributor.author |
Kanui, Titus I. |
|
dc.contributor.author |
Githinji, C. G. |
|
dc.contributor.author |
Mbugua, P. M. |
|
dc.contributor.author |
Kariuki, D. K. |
|
dc.date.accessioned |
2015-06-02T09:16:51Z |
|
dc.date.available |
2015-06-02T09:16:51Z |
|
dc.date.issued |
2011 |
|
dc.identifier.citation |
International Journal of Phytopharmacology, 2011; Volume 2(2): 70–75 |
en_US |
dc.identifier.issn |
2229-7472 |
|
dc.identifier.uri |
www.onlineijp.com/download.php?id=115&f=115_70-75.pdf |
|
dc.identifier.uri |
http://repository.seku.ac.ke/handle/123456789/1277 |
|
dc.description.abstract |
Mondiawhytei is used for treatment of dysmennorrhea, gastro intestinal colic, post-partum pains among other uses in the practice of traditional medicine in Africa.In the present study, the in vivoantinociceptive effects of two compounds,stigmasterol and 9-hexacosene isolated fromMondiawhytei roots has been investigated.Bioactivity guided extraction and isolation of stigmasterol and 9-hexacosene was carried out.The formalin test was used inassessing the antinociceptive activity.Stigmasterol reduced the time spent licking, biting and/or lifting the injected paw in both the early and late phases of the formalin test. This reduction was found to be dose dependent and statistically significant (p<0.001) at a dose of 30mg/kg body weight.9-hexacoseneproduced dose-dependent and statistically significant (p<0.001) antinociceptive effect on the late phase of the formalin test at a dose of 7.5mg/kg body weight.No motor, neurological or other behavioral deficits were observed.Conclusion:Results of the present study supported the utilization of Mondiawhytei in Africa folk medicine and revealed stigmasterol and 9-hexacosene as the major antinociceptive principles in the roots. |
en_US |
dc.language.iso |
en |
en_US |
dc.subject |
Mondiawhytei |
en_US |
dc.subject |
antinociception |
en_US |
dc.subject |
Stigmasterol |
en_US |
dc.subject |
9-hexacosene |
en_US |
dc.subject |
formalin test |
en_US |
dc.title |
Antinociceptive effects of stigmasterol and 9-hexacosene isolated from mondia whytei(hook.f.) root |
en_US |
dc.type |
Article |
en_US |