dc.contributor.author |
Mulinge, Martin M. |
|
dc.contributor.author |
Zheng, Y. |
|
dc.contributor.author |
Counson, M. |
|
dc.contributor.author |
Yang, X. |
|
dc.contributor.author |
Steinmetz, A. |
|
dc.contributor.author |
Schmit, J. C. |
|
dc.contributor.author |
Devaux, C. |
|
dc.date.accessioned |
2015-04-09T07:13:22Z |
|
dc.date.available |
2015-04-09T07:13:22Z |
|
dc.date.issued |
2014 |
|
dc.identifier.citation |
Planta Medica 2014; 80 - PD119 |
en_US |
dc.identifier.issn |
0032-0943 |
|
dc.identifier.uri |
https://www.thieme-connect.com/products/ejournals/abstract/10.1055/s-0034-1382540 |
|
dc.identifier.uri |
http://repository.seku.ac.ke/handle/123456789/1138 |
|
dc.description |
DOI: 10.1055/s-0034-1382540 |
en_US |
dc.description.abstract |
To avoid long-term toxicity and drug resistance of HIV, new treatment involving the use of novel antiviral medicines is recommended. We have studied the anti-HIV activity of a crude extract and several purified compounds from an African plant. The crude extract inhibited HIV-1 replication on several cell lines and also on human PBMCs at non-toxic concentrations. It strongly inhibited HIV infection but not VSV infection of U373-CD4-CXCR4/CCR5 cells independently of co-receptor usage (IC50 between 3 and 12 µg/ml, respectively). The extract inhibited HIV-1 when added at the time of infection but not after infection. The antiviral activity of the extract was maintained when it was pre-incubated with the virus but not with the cells. These data suggest that the extract might act on the early process of HIV infection. In addition, the extract displayed a synergistic effect with fusion inhibitor as well as with co-receptor inhibitors suggesting that the extract may have other activity such as protease or integrase inhibitors. Purified compounds have been tested on U373-CD4-CXCR4/CCR5 cells against pseudotype viruses. Four compounds showed anti-HIV activity. More in-depth studies are in progress. |
en_US |
dc.language.iso |
en |
en_US |
dc.publisher |
Georg Thieme Verlag |
en_US |
dc.title |
Anti-HIV activities in an African plant extract |
en_US |
dc.type |
Article |
en_US |