dc.contributor.author |
Kisangau, Daniel P. |
|
dc.contributor.author |
Devkota, Krishna P. |
|
dc.contributor.author |
Lenta, Bruno N. |
|
dc.contributor.author |
Wansi, Jean D. |
|
dc.contributor.author |
Choudhary, Muhammad I. |
|
dc.contributor.author |
Samreen, Qamar N. |
|
dc.contributor.author |
Sewald, Norbert |
|
dc.date.accessioned |
2014-11-21T06:51:34Z |
|
dc.date.available |
2014-11-21T06:51:34Z |
|
dc.date.issued |
2008 |
|
dc.identifier.citation |
Journal of Natural Products 2008, 71 (8), pp 1481–1484 |
en_US |
dc.identifier.issn |
0163-3864 |
|
dc.identifier.uri |
http://pubs.acs.org/doi/abs/10.1021/np800305b |
|
dc.identifier.uri |
http://hdl.handle.net/123456789/107 |
|
dc.description |
DOI: 10.1021/np800305b |
en_US |
dc.description.abstract |
The bioassay-guided phytochemical investigation of Sarcococca hookeriana with respect to cholinesterase inhibitory properties has yielded two new 5α-pregnane-type steroidal alkaloids, hookerianamides J (1) and K (2), along with eight known compounds (3−10). The structures of 1 and 2 were elucidated by spectroscopic methods. These compounds displayed good to moderate activities in vitro against the enzymes acetylcholinesterase (IC50 8.1−48.5 μM) and butyrylcholinesterase (IC50 0.4−4.0 μM). Compounds 1−10 were also tested in vitro for their leishmanicidal activity against Leishmania major and for their antibacterial activities against Bacillus subtilis, Micrococcus luteus, Streptococcus faecalis, and Pseudomonas pallida. |
en_US |
dc.publisher |
American Chemical Society |
en_US |
dc.title |
Bioactive 5α-Pregnane-Type Steroidal Alkaloids from Sarcococca hookeriana |
en_US |