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Antinociceptive effects of nortriptyline and desipramine hydrochloride in Speke's hinge-back tortoise (Kinixys Spekii)

Makau, Christopher M.; Towett, Philemon K.; Kanui, Titus I.; Abelson, Klas S. (Wiley, 2023-01-23)

Some of the most commonly used analgesic drugs in animals are of questionable efficacy or present adverse side effects among the various species of reptiles. Tricyclic antidepressants have been demonstrated to have ...
Antinociceptive effects of stigmasterol and 9-hexacosene isolated from mondia whytei(hook.f.) root

Kanui, Titus I.; Githinji, C. G.; Mbugua, P. M.; Kariuki, D. K. (2011)

Mondiawhytei is used for treatment of dysmennorrhea, gastro intestinal colic, post-partum pains among other uses in the practice of traditional medicine in Africa.In the present study, the in vivoantinociceptive effects ...
Antinociceptive potentiation of pethidine (demerol) by clomipramine in the late phase of formalin test in mice

Kanui, Titus I.; Kariuki, Hellen N.; Kioy, Paul G. (African Field Epidemiology Network, 2012)

Background: Pethidine, an opioid analgesic is used for pain management. Clomipramine a tricyclic antidepressant primarily used for mood management is also used to treat pain. The objective of this study was to investigate ...
Antinocieptive and anti-inflammatory effects of Toddalia asiatica (L) Lam. (Rutaceae) root extract in Swiss albino mice

Kanui, Titus I.; Kariuki, Hellen N.; Yenesew, Abiy; Patel, Nilesh; Mbugua, Paul M. (2013)

Introduction Toddalia asiatica is a commonly used medicinal plant in East Africa for the management of pain and inflammatory conditions. The present study investigated the antinociceptive and the anti-inflammatory effects ...
Effects of inhibition of Nav1.3, Nav1.7, and Nav1.8 channels on pain-related behavior in Speke's hinge-back tortoise (Kinixys spekii)

Makau, Christopher M.; Towett, Philemon K.; Kanui, Titus I.; Abelson, Klas S. (2023-11-27)

Comparative studies using reptiles as experimental animals in pain research could expand our knowledge on the evolution and adaptation of pain mechanisms. Currently, there are no data reported on the involvement of ...
Investigation of the presence and antinociceptive function of muscarinic acetylcholine receptors in the African naked mole-rat (Heterocephalus glaber)

Kanui, Titus I.; Jørgensen, K. B.; Krogh-Jensen, K.; Pickering, D. S.; Abelson, K. S. (Springer Berlin Heidelberg, 2016-01)

The present study investigated the cholinergic system in the African naked mole-rat (Heterocephalus glaber) with focus on the muscarinic acetylcholine receptor subtypes M1 and M4. The protein sequences for the subtypes m ...
Modulation of nociception by amitriptyline hydrochloride in the Speke's hinge-back tortoise (Kiniskys spekii)

Makau, Christopher M.; Towett, Philemon K.; Abelson, Klas S. P.; Kanui, Titus I. (John Wiley & Sons Ltd, 2021-02)

Background: There are limited studies on the utilization of analgesics in testudines. Management of pain in reptiles is by use of analgesics generally used in other vertebrate species. Evidently, some analgesics considered ...

Browsing by Subject "formalin test"

Browsing by Subject "formalin test"

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