Phytochemical and analgesic evaluation of Mondia whytei (hook.f) root

Abstract

Mondia whytei is a forest floor plant that belongs to Asclepidaceae family. The roots are widely used in African traditional medicine to treat various diseases and conditions that include pain, swelling, postpartum hemorrhage, diabetes mellitus among many other claims. Phytochemical tests were carried out to determine the different chemical constituents of the root skeels of M. whytei. Analgesic activity of the root powder was evaluated using acetic acid induced writhing test. Phytochemical screening revealed the presence of carotenoids, flavonoids, steroids and tannins. The root skeels significantly (p < 0.05) reduced the number of writhes in acetic acid induced writhing test. This reduction was dose-dependent. Therefore, the use of the plant by traditional medical practitioners in the treatment of pain may be justified.