dc.contributor.author |
Karanja, J. K. |
|
dc.contributor.author |
Kiboi, Nathan G. |
|
dc.contributor.author |
Nebere, S. N. |
|
dc.contributor.author |
Achieng, H. O. |
|
dc.date.accessioned |
2022-06-16T06:42:13Z |
|
dc.date.available |
2022-06-16T06:42:13Z |
|
dc.date.issued |
2016 |
|
dc.identifier.citation |
Journal of Drug Metabolism and Toxicology, Volume 7, Issue 2 |
en_US |
dc.identifier.issn |
2157-7609 |
|
dc.identifier.uri |
https://www.longdom.org/open-access/highly-active-antiretroviral-therapy-and-antituberculosis-druginteractions-with-associated-clinical-implications-a-review-2157-7609-1000207.pdf |
|
dc.identifier.uri |
http://repository.seku.ac.ke/handle/123456789/6813 |
|
dc.description |
DOI: 10.4172/2157-7609.1000207 |
en_US |
dc.description.abstract |
Tuberculosis is the most common opportunistic infection associated with HIV/AIDS, and remains a disease of
global significance. Co-infection with HIV complicates proper TB diagnosis and therapeutic outcomes. Profound
immunosuppression characterizes HIV/TB co-infection prompting early initiation of HAART during TB treatment.
Effective management of the co-infection requires concomitant administration of ART and anti-tuberculosis drugs;
however, this therapeutic approach has had its fair share of challenges including: overlapping drug toxicities, drugdrug interactions and immune reconstitution reactions. For instance, combination of nevirapine-based ART and
rifampicin-based TB treatment is reported to cause hepatotoxicity in healthy volunteers. As such, this review
compiles information from multiple studies describing drug interactions associated with co-treatments, with a view to
improving management of these co-morbidities. |
en_US |
dc.language.iso |
en |
en_US |
dc.subject |
Antiretroviral therapy |
en_US |
dc.subject |
Co-infection |
en_US |
dc.subject |
Drug interactions |
en_US |
dc.subject |
Tuberculosis |
en_US |
dc.subject |
HIV |
en_US |
dc.title |
Highly active antiretroviral therapy and anti-tuberculosis drug interactions with associated clinical implications: a review |
en_US |
dc.type |
Article |
en_US |