dc.contributor.author |
Kanui, Titus I. |
|
dc.contributor.author |
Towett, Phelimon K. |
|
dc.date.accessioned |
2015-01-20T06:53:33Z |
|
dc.date.available |
2015-01-20T06:53:33Z |
|
dc.date.issued |
1993-05 |
|
dc.identifier.citation |
Pharmacology Biochemistry and Behavior Volume 45, Issue 1, May 1993, Pages 153–159 |
en_US |
dc.identifier.uri |
http://www.sciencedirect.com/science/article/pii/009130579390099F |
|
dc.identifier.uri |
http://hdl.handle.net/123456789/631 |
|
dc.description |
doi:10.1016/0091-3057(93)90099-F |
|
dc.description.abstract |
The antinociceptive and behavioral effects of pethidine (10, 20, or 30 mg/kg), acetylsalicylic acid (200, 400, or 600 mg/kg) and indomethacin (20, 40, or 50 mg/kg) in the naked mole-rat was studied in the hot-plate test. Instead of inducing analgesia, pethidine caused a dose-dependent reduction in response latency. Sensorimotor impairment and aggressive behavior were also observed following administration of pethidine (20 or 30 mg/kg). All animals recieving pethidine (30 mg/kg) died following fighting when kept in colony cages. Aggressive behavior and death was prevented by naloxone or by keeping animals in single cages. Acetylsalicylic acid (600 mg/kg) and indomethacin (40 or 50 mg/kg) caused a significant increase in response latency. It is concluded that in the mole-rat pethidine elicits aggression, sensorimotor impairment, and apparent hypergesia. |
en_US |
dc.language.iso |
en |
en_US |
dc.publisher |
Elsevier |
en_US |
dc.subject |
Pethidine |
en_US |
dc.subject |
NSAIDs |
en_US |
dc.subject |
Nociception |
en_US |
dc.subject |
Aggression |
en_US |
dc.subject |
Sensorimotor impairment |
en_US |
dc.subject |
Hot-plate test |
en_US |
dc.subject |
Naked mole-rat |
en_US |
dc.title |
Effects of pethidine, acetylsalicylic acid, and indomethacin on pain and behavior in the mole-rat |
en_US |
dc.type |
Article |
en_US |