Molecular genetic diversity of hepatitis B virus in Kenya

Ng'ang'a, Zipporah W.; Mwangi, Joseph; Songok, Elijah; Kinyua, Joyceline; Lagat, Nancy; Muriuki, Joseph; Lihana, Raphael; Khamadi, Samoel; Osman, Saida; Lwembe, Raphael; Kiptoo, Michael K.; Mwau, Matilu; Chirchir, Ruth; Mpoke, Solomon; Nyamongo, Jack; Okoth, Fred; Yamada, Rika; Kageyama, Seiji; Ichimura, Hiroshi

dc.contributor.author	Ng'ang'a, Zipporah W.
dc.contributor.author	Mwangi, Joseph
dc.contributor.author	Songok, Elijah
dc.contributor.author	Kinyua, Joyceline
dc.contributor.author	Lagat, Nancy
dc.contributor.author	Muriuki, Joseph
dc.contributor.author	Lihana, Raphael
dc.contributor.author	Khamadi, Samoel
dc.contributor.author	Osman, Saida
dc.contributor.author	Lwembe, Raphael
dc.contributor.author	Kiptoo, Michael K.
dc.contributor.author	Mwau, Matilu
dc.contributor.author	Chirchir, Ruth
dc.contributor.author	Mpoke, Solomon
dc.contributor.author	Nyamongo, Jack
dc.contributor.author	Okoth, Fred
dc.contributor.author	Yamada, Rika
dc.contributor.author	Kageyama, Seiji
dc.contributor.author	Ichimura, Hiroshi
dc.date.accessioned	2014-12-03T10:51:01Z
dc.date.available	2014-12-03T10:51:01Z
dc.date.issued	2008
dc.identifier.citation	Intervirology. 2008;51(6):417-21.	en_US
dc.identifier.uri	http://www.researchgate.net/publication/24174998_Molecular_genetic_diversity_of_hepatitis_B_virus_in_Kenya
dc.identifier.uri	http://hdl.handle.net/123456789/309
dc.description	doi: 10.1159/000205526.	en_US
dc.description.abstract	Eight genotypes of hepatitis B virus (A-H) and subgenotypes have been recognized worldwide. However, there is limited information on prevalent genotypes in many countries in Africa. This study was undertaken to determine the hepatitis B virus (HBV) genotypes in Kenya. Seropositive HBV blood samples from a blood donor setting were used in the study. HBV genotypes were determined in 52 nucleic acid-positive samples using specific primer in a nested PCR and sequencing employed in the HBV genotyping. This study shows presence of HBV variants with genotypes A (88%), E (8%) and D (4%). In conclusion, we found that HBV genotype A is the most predominant genotype in Kenya with both subgenotype A1 and A2 present. Genotype D and E are also present in our population. This demonstrates that there could be a high genetic diversity of HBV in Kenya. Copyright 2009 S. Karger AG, Basel.	en_US
dc.language.iso	en	en_US
dc.publisher	S. Karger AG, Basel	en_US
dc.subject	Genotypes	en_US
dc.subject	Hepatitis B virus	en_US
dc.subject	Kenya	en_US
dc.subject	Nuclear acid testing	en_US
dc.title	Molecular genetic diversity of hepatitis B virus in Kenya	en_US
dc.type	Article	en_US