dc.contributor.author |
Ng'ang'a, Zipporah W. |
|
dc.contributor.author |
Muok, Erick M. O. |
|
dc.contributor.author |
Simiyu, Elses W. |
|
dc.contributor.author |
Ochola, Elizabeth A. |
|
dc.contributor.author |
Secor, W. Evan |
|
dc.contributor.author |
Karanja, Diana M. S. |
|
dc.contributor.author |
Mwinzi, Pauline N. M. |
|
dc.date.accessioned |
2014-12-01T07:07:57Z |
|
dc.date.available |
2014-12-01T07:07:57Z |
|
dc.date.issued |
2013 |
|
dc.identifier.citation |
Am. J. Trop. Med. Hyg., 89(1), 2013, pp. 42–45 |
en_US |
dc.identifier.uri |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3748485/ |
|
dc.identifier.uri |
http://hdl.handle.net/123456789/256 |
|
dc.description |
doi:10.4269/ajtmh.13-0045 |
en_US |
dc.description.abstract |
Previously, we have shown that persons with human immunodeficiency virus 1 (HIV-1) infection and
reduced CD4+ T-lymphocyte counts excrete significantly fewer Schistosoma mansoni eggs than HIV-1–negative persons
with similar intensities of schistosome infections. To determine how antiretroviral therapy (ART) might affect egg
excretion, we conducted a study of HIV+ adults living in an area highly endemic for S. mansoni as they began an ART
program.FecaleggexcretionandCD4+T-lymphocytecountswereevaluatedatenrollmentaswellas2and4weeksafter
initiation of ART. Fourteen individuals who were Kato–Katz-negative at enrollment subsequently started excreting
S. mansoni eggs accompanied by a significant increase in CD4+ T lymphocytes ( P= 0.004). Study participants who were
S. mansoniegg-positiveatenrollmentandreceivedbothpraziquantelandARTalsoshowedsignificantlyincreasedCD4 +
T-lymphocyte counts compared with baseline ( P< 0.0001). Our data support a role for CD4+ T lymphocytes in
S. mansoni egg excretion. |
en_US |
dc.language.iso |
en |
en_US |
dc.publisher |
The American Society of Tropical Medicine and Hygiene |
en_US |
dc.title |
Association between CD4 + T-Lymphocyte counts and fecal excretion of schistosoma mansoni eggs in patients coinfected with S. mansoni and Human Immunodeficiency Virus before and after Initiation of antiretroviral therapy |
en_US |
dc.type |
Article |
en_US |