dc.contributor.author |
Ng'ang'a, Zipporah W. |
|
dc.contributor.author |
Kiptoo, Michael K. |
|
dc.contributor.author |
Ichimura, Hiroshi |
|
dc.contributor.author |
Wembe, Raphael L. |
|
dc.contributor.author |
Mueke, Jones |
|
dc.contributor.author |
Kinyua, Joyceline |
|
dc.contributor.author |
Lagat, Nancy |
|
dc.contributor.author |
Okoth, Fredrick |
|
dc.contributor.author |
Songok, E. M. |
|
dc.date.accessioned |
2014-11-27T07:05:08Z |
|
dc.date.available |
2014-11-27T07:05:08Z |
|
dc.date.issued |
2008 |
|
dc.identifier.citation |
AIDS RESEARCH AND HUMAN RETROVIRUSES Volume 24, Number 12, 2008 |
en_US |
dc.identifier.uri |
http://hdl.handle.net/123456789/196 |
|
dc.description |
DOI: 10.1089/aid.2008.0018 |
en_US |
dc.description.abstract |
The use of single dose nevirapine to prevent mother-to-child transmission of HIV has been reported to induce
drug-resistant mutations and reduce options for antiretroviral treatment for HIV-infected mothers and their
children. To explore the status of nevirapine-resistant HIV genotypes in rural hospitals in the North Rift Valley
Province of Kenya, samples collected 3 months after single dose nevirapine from 36 mothers and their children
were analyzed. Resistance mutations were genotypically evaluated through proviral DNA amplification,
cloning, and sequencing. Ten mothers (27.8%) had antiretroviral-associated resistance mutations of whom four
(11.1%) had specific nevirapine (NNRTI) resistance-associated mutations. Three mothers (8.3%) transmitted the
infection to their infants. This presence of nevirapine mutations in rural antenatal clinic attendees confirms the
importance of integrating antiretroviral resistance monitoring as a key component in programs geared to prevention
of HIV mother-to-child transmission. |
en_US |
dc.language.iso |
en |
en_US |
dc.publisher |
Mary Ann Liebert, Inc. |
en_US |
dc.title |
Prevalence of nevirapine-associated resistance mutations after single dose prophylactic treatment among antenatal clinic attendees in North Rift Kenya |
en_US |
dc.type |
Article |
en_US |