dc.contributor.author |
Kanui, Titus I. |
|
dc.contributor.author |
Karim, F. |
|
dc.contributor.author |
Towett, P. K. |
|
dc.date.accessioned |
2015-06-02T06:52:26Z |
|
dc.date.available |
2015-06-02T06:52:26Z |
|
dc.date.issued |
1993-01-08 |
|
dc.identifier.citation |
Brain Research Volume 600, Issue 1, 8 January 1993, Pages 123–126 |
en_US |
dc.identifier.issn |
0006-8993 |
|
dc.identifier.uri |
http://www.sciencedirect.com/science/article/pii/000689939390409G |
|
dc.identifier.uri |
http://repository.seku.ac.ke/handle/123456789/1273 |
|
dc.description |
doi:10.1016/0006-8993(93)90409-G |
en_US |
dc.description.abstract |
The present experiments were initiated to study the effects of morphine, nefopam and paracetamol in the naked mole-rat, a hairless rodent that lives in subterranean colonies of up to 300, following the inability to demonstrate morphine analgesia in the hot-plate test in the rodent. The formalin test was used. Injection of 20 μl 10% formalin produced two periods of high licking and pain behaviour, the early (0–5 min) and the late phase (15–60 min). Morphine (10 or 20 mg/kg), nefopam (10 or 20 mg/kg) and paracetamol (200 mg/kg) significantly inhibited the two phases. Paracetamol (400 mg/kg) produced significant analgesia only during the late phase. It is concluded that, unlike in the hot-plate test, it is possible to demonstrate the analgesic effects of morphine in the naked mole-rat, in the formalin test. |
en_US |
dc.language.iso |
en |
en_US |
dc.publisher |
Elsevier |
en_US |
dc.subject |
Naked mole-rat |
en_US |
dc.subject |
Formalin test |
en_US |
dc.subject |
Pain |
en_US |
dc.subject |
Opioid |
en_US |
dc.subject |
Non-opioid |
en_US |
dc.title |
The formalin test in the naked mole-rat (Heterocephalus glaber): analgesic effects of morphine, nefopam and paracetamol |
en_US |
dc.type |
Article |
en_US |