Bioactive 5α-Pregnane-Type Steroidal Alkaloids from Sarcococca hookeriana

Kisangau, Daniel P.; Devkota, Krishna P.; Lenta, Bruno N.; Wansi, Jean D.; Choudhary, Muhammad I.; Samreen, Qamar N.; Sewald, Norbert

dc.contributor.author	Kisangau, Daniel P.
dc.contributor.author	Devkota, Krishna P.
dc.contributor.author	Lenta, Bruno N.
dc.contributor.author	Wansi, Jean D.
dc.contributor.author	Choudhary, Muhammad I.
dc.contributor.author	Samreen, Qamar N.
dc.contributor.author	Sewald, Norbert
dc.date.accessioned	2014-11-21T06:51:34Z
dc.date.available	2014-11-21T06:51:34Z
dc.date.issued	2008
dc.identifier.citation	Journal of Natural Products 2008, 71 (8), pp 1481–1484	en_US
dc.identifier.issn	0163-3864
dc.identifier.uri	http://pubs.acs.org/doi/abs/10.1021/np800305b
dc.identifier.uri	http://hdl.handle.net/123456789/107
dc.description	DOI: 10.1021/np800305b	en_US
dc.description.abstract	The bioassay-guided phytochemical investigation of Sarcococca hookeriana with respect to cholinesterase inhibitory properties has yielded two new 5α-pregnane-type steroidal alkaloids, hookerianamides J (1) and K (2), along with eight known compounds (3−10). The structures of 1 and 2 were elucidated by spectroscopic methods. These compounds displayed good to moderate activities in vitro against the enzymes acetylcholinesterase (IC50 8.1−48.5 μM) and butyrylcholinesterase (IC50 0.4−4.0 μM). Compounds 1−10 were also tested in vitro for their leishmanicidal activity against Leishmania major and for their antibacterial activities against Bacillus subtilis, Micrococcus luteus, Streptococcus faecalis, and Pseudomonas pallida.	en_US
dc.publisher	American Chemical Society	en_US
dc.title	Bioactive 5α-Pregnane-Type Steroidal Alkaloids from Sarcococca hookeriana	en_US