dc.contributor.author |
Kanui, Titus I. |
|
dc.contributor.author |
Towett, Philemon K. |
|
dc.contributor.author |
Juma, Francis |
|
dc.contributor.author |
Ole Miaron, Jacob Olongida |
|
dc.contributor.author |
Ole Maloiy, Geoffrey M. |
|
dc.date.accessioned |
2015-01-20T08:25:22Z |
|
dc.date.available |
2015-01-20T08:25:22Z |
|
dc.date.issued |
2009-02 |
|
dc.identifier.citation |
Pharmacology Biochemistry and Behavior Volume 91, Issue 4, February 2009, Pages 566–572 |
en_US |
dc.identifier.uri |
http://www.sciencedirect.com/science/article/pii/S0091305708003250 |
|
dc.identifier.uri |
http://hdl.handle.net/123456789/635 |
|
dc.description |
doi:10.1016/j.pbb.2008.09.011 |
|
dc.description.abstract |
Data available on the role of the opioid systems of the naked mole-rat in nociception is scanty and unique compared to that of other rodents. In the current study, the effect of DAMGO, DPDPE and U-50488 and U-69593 on formalin-induced (20 μl, 10%) nociception were investigated. Nociceptive-like behaviors were quantified by scoring in blocks of 5 min the total amount of time (s) the animal spent scratching/biting the injected paw in the early (0–5 min) and in the late (25–60 min) phase of the test. In both the early and late phases, administration of 1 or 5 mg/kg of DAMGO or DPDPE caused a naloxone-attenuated decrease in the mean scratching/biting time. U-50488 and U-69593 at all the doses tested did not significantly change the mean scratching/biting time in the early phase. However, in the late phase U-50488 or U-69593 at the highest doses tested (1 or 5 mg/kg or 0.025 or 0.05 mg/kg, respectively) caused a statistically significant and naloxone-attenuated decrease in the mean scratching/biting time. The data showed that mu, delta or kappa-selective opioids causes antinociception in the formalin test in this rodent, adding novel information on the role of opioid systems of the animal on pain regulation. |
en_US |
dc.language.iso |
en |
en_US |
dc.publisher |
Elsevier |
en_US |
dc.subject |
Formalin test |
en_US |
dc.subject |
Naked mole-rat |
en_US |
dc.subject |
Nociception |
en_US |
dc.subject |
Antinociception |
en_US |
dc.subject |
DAMGO |
en_US |
dc.subject |
DPDPE |
en_US |
dc.subject |
U-50488 |
en_US |
dc.subject |
U-69593 |
en_US |
dc.title |
Activation of mu, delta or kappa opioid receptors by DAMGO, DPDPE, U-50488 or U-69593 respectively causes antinociception in the formalin test in the naked mole-rat (Heterocephalus glaber) |
en_US |
dc.type |
Article |
en_US |