dc.contributor.author |
Waitumbi, John N. |
|
dc.contributor.author |
Kifude, Carolyne M. |
|
dc.contributor.author |
Hunja, Carol W. |
|
dc.contributor.author |
Ogutu, Bernhards R. |
|
dc.date.accessioned |
2019-05-20T09:49:11Z |
|
dc.date.available |
2019-05-20T09:49:11Z |
|
dc.date.issued |
2018-09 |
|
dc.identifier.citation |
PLoS ONE,13(9): e0203455 |
en_US |
dc.identifier.uri |
https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0203455&type=printable |
|
dc.identifier.uri |
http://repository.seku.ac.ke/handle/123456789/4444 |
|
dc.description |
https://doi.org/10.1371/journal.pone.0203455 |
en_US |
dc.description.abstract |
The quantity of the intra-erythrocytic deoxyhemoglobin S (Hb S) affects the level of protection against malaria and also the sickling phenomenon. This study reports on significantly
lower concentration of Hb S in females than males. Data came from 350 children, aged 12–
47 months who participated in a phase 2b malaria vaccine trial. Hemoglobinopathy and
G6PD deficiency typing was necessary to ascertain equal representation of these malaria
protective traits across the vaccine cohorts. Hemoglobin types (HbAA, HbAS) and % Hb S
were evaluated by HPLC. Alpha thalassemia (alpha-thal) and G6PD genotypes were evaluated by PCR. The overall prevalence for HbAS was 20%, 46% for 3 alpha genes and 10%
for 2 alpha genes and 14% for G6PD A-. More females of HbAS/αα/αα genotype had low Hb
S than males and had mean % Hb S of 37.5% ± 5.4 SD, compared to 42.0% ± 2.5 SD in
males of same genotype (P = 0.018). Consistent with reduction of the malaria protective Hb
S in females, parasite load in females was nearly twice that of males but the difference was
not statistically significant. The X-chromosome linked G6PD deficiency did not influence the
level of Hb S. We conclude that, the low Hb S in these females explains the resultant higher
malaria parasite load. We speculate that the low Hb S in females could also explain observations suggesting that the sickling phenomenon tends to be less severe in females than
males. |
en_US |
dc.language.iso |
en |
en_US |
dc.publisher |
Public Library of Science |
en_US |
dc.title |
Females of HbAS genotype have reduced concentration of the malaria protective deoxyhemoglobin S than males |
en_US |
dc.type |
Article |
en_US |